What is Cymbalta?
Cymbalta (known also as Duloxetine) is a Serotonin Norepinephrine Reuptake Inhibitor (SSNRI) produced by Eli Lilly HelthCare company. Duloxetine affects some organic substances in the patient's brain that might unbalance themselves, thus causins depression or other nervous disorders. Duloxetine is widely used for treating Major Depressive Disorders (MDDs) and General Anxiety Disorders (GADs). Cymbalta medication is also prescribed for chronic pain disorder know better as Fibromyalgia and pain caused by nerve damage in diabetes patients. Duloxetine appears to be inferior to the some other popular antidepressants like Sertraline Hydrochloride (Zoloft) and Escitalopram.
Cymbalta capsules are white to brownish white, partially soluble in water. Each capsule contains 20mg, 30mg, or 60 mg of Duloxetine, depending on your subscription. The 20 and 60 mg pills contain some iron oxide as a passive ingredient.
In 2001 Eli Lilly submitted a New Drug Application (NDA) for Cymbalta medication with FDA, but failed the approval for concerns about liver toxicity and some unrelated suicidal events. Citing FDA: "Cymbalta may be a drug that is related to liver injury, but there are no cases in the NDA database that clearly denote this".
Duloxetine was approved for use of stress urinary incontinence (SUI) in the EU in 2004, in the U.S. Eli Lilly withdrew the Duloxetine application for SUI in the next year, and a year later Lilly abandoned the pursuit of this indication in the U.S. market.
In 2004, Duloxetine was approved by the FDA for treating depression and diabetic neuropathy, and in 2007 Health Canada also gave green light to Cymbalta.